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Topical Treatments for Vaginal Atrophy

Tuesday, July 25, 2017   (0 Comments)
Posted by: Brook Schales
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Written by Suzanne Rosenberg, RPH

Vaginal atrophy may be treated with a variety of creative preparations. Treatments are mosteffective when applied locally in the form of a cream or suppository.

  • Estradiol (E2) is available commercially as a 0.01% cream. Estriol (E3), a much weaker form of estrogen can be prepared by a compounding pharmacy, typically at a strength of 0.05%-0.2%.
  • In addition to estrogen, the hormone DHEA has recently been proven to relieve the symptoms of vaginal atrophy and regenerate the tissue’s cell growth1. Recent research of topically applied DHEA shows little, if any systemic absorption1. DHEA may also have some localized testosterone effects as it can be converted to either hormone.
  • These hormones may be prescribed alone, or in combination with non-hormonal treatments such as vitamin E, cocoa butter, estrogenic herbs as well as hyaluronic acid.
  • Creative hormonal formula:
    E3 0.05%/DHEA 10mg/VitE 100IU/dose with cocoa butter vaginal suppository or cream
  • Creative non-hormonal formula:
    Hyaluronic Acid 5mg/VitE 100IU/dose with cocoa butter vaginal suppository or cream


Menopause: The Journal of the North American Menopause Society Vol. 16, No. 5, pp. 907/922 DOI: 10.1097/gme.0b013e31819e8e2d * 2009 by The North American Menopause Society
Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy Fernand Labrie, MD, PhD,1,2 David Archer, MD,3 Ce´line Bouchard, MD,4
Michel Fortier, MD,4 Leonello Cusan, MD, PhD,1 Jose´-Luis Gomez, MD, PhD,1 Ginette Girard, MD,5 Mira Baron, MD,6 Normand Ayotte, MD,7 Miche`le Moreau, MD,8 Robert Dube´, MD,9 Isabelle
Coˆte´, BSc CCRP,2 Claude Labrie, MD, PhD,1,2 Lyne Lavoie, MSc,2 Louise Berger, PhD,2 Lucy Gilbert, MD,10 Ce´line Martel, PhD,2 and John Balser, PhD11


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